COL3A1

Across TCGA pan-cancer cohorts, COL3A1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COL3A1 data layer compared with 23 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher COL3A1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COL3A1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CCRCC, LSCC, and COAD are the cancer types where COL3A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.240	0.985	.013	21	view →
LSCC	DFS	Tertile	II,III,IV	0.470	0.800	.013	18	view →
COAD	DFS	Median	III,IV	0.838	1.000	.037	12	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
UCEC	DFS	Median	All	1.000	0.937	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

COL3A1–CCRCC (DFS)

Open the CCRCC breakdown →