COL3A1

Across TCGA patient cohorts, COL3A1 mutation is significantly associated with the RNA expression of many other genes, with 6,561 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL3A1-associated genes across cancer lineages are CHEK1, SUPV3L1, and GTSE1. Each is linked with COL3A1 in more than 4 cancer types. Because this analysis shows association rather than direction, both COL3A1-to-partner and partner-to-COL3A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHEK1 grouped by COL3A1-low versus COL3A1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL3A1→partner) and Y-score (partner→COL3A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CHEK1 →	+0.568	+1.679	<.001	.001	3	5
SKCM	SUPV3L1 →	+0.201	+1.436	.007	.001	3	5
LUAD	GTSE1 →	+0.740	+2.087	<.001	<.001	3	4
COAD	MCM6 →	+0.576	+3.114	<.001	<.001	3	4
LUAD	SPAG5 →	+0.830	+1.893	<.001	<.001	3	4
LUAD	UBE2T →	+0.918	+1.904	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,561 associations by consensus.

CHEK1 by COL3A1 expression — LUAD

Explore this box plot interactively →