COL3A1

Across TCGA cell cohorts, COL3A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,579 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible COL3A1-associated GO terms across cancer lineages are Negative regulation of endodermal cell differentiation, Metanephric glomerulus morphogenesis, and Metanephric glomerulus vasculature morphogenesis. Each is linked with COL3A1 in more than 12 cancer types. Because this analysis shows association rather than direction, both COL3A1-to-partner and partner-to-COL3A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of endodermal cell differentiation grouped by COL3A1-low versus COL3A1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COL3A1→partner) and Y-score (partner→COL3A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of endodermal cell differentiation →	+0.843	+1.861	<.001	<.001	3	13
BREAST	Metanephric glomerulus morphogenesis →	+0.740	+3.029	.007	.003	3	8
BREAST	Metanephric glomerulus vasculature morphogenesis →	+0.740	+3.029	.007	.003	3	8
BREAST	Metanephric glomerular capillary formation →	+0.740	+3.029	.007	.003	3	8
SKIN	Positive regulation of protein catabolic process →	+0.040	+2.588	<.001	.004	3	8
UPPER_AERODIGESTIVE_TRACT	Golgi vesicle transport →	+0.056	+2.170	.004	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,579 associations by consensus.

Negative regulation of endodermal cell differentiation by COL3A1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →