COL2A1

Across TCGA pan-cancer cohorts, COL2A1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated COL2A1 data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher COL2A1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated COL2A1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where COL2A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.881	0.488	.001	54	view →
PDAC	OS	Tertile	All	0.373	0.618	.001	52	view →
LSCC	DFS	Median	II,III,IV	0.633	0.903	.008	17	view →
LUAD	DFS	Median	All	0.852	0.686	.020	13	view →
HNSC	OS	Quartile	II,III,IV	0.929	1.000	.038	4	view →
GBM	DFS	Tertile	All	0.636	0.856	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

COL2A1–CCRCC (DFS)

Open the CCRCC breakdown →