Across TCGA pan-cancer cohorts, COL28A1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated COL28A1 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher COL28A1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated COL28A1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where COL28A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.611	0.816	.007	18	view →
PDAC	DFS	Median	III,IV	0.484	0.238	.008	10	view →
LUAD	DFS	Tertile	II,III,IV	0.279	0.884	.010	9	view →
GBM	OS	Median	All	0.488	0.277	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: COL28A1 tumor-vs-normal RNA expression · all COL28A1 data types