Across TCGA cell cohorts, COL28A1 mutation is significantly associated with the RNA expression of many other genes, with 159 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COL28A1-associated genes across cancer lineages are RPP38, ZIC3, and ATXN3L. Each is linked with COL28A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COL28A1-to-partner and partner-to-COL28A1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL28A1→partner) and Y-score (partner→COL28A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RPP38 →	+0.529	+3.212	.004	.006	3	2
BLOOD_Lymphoma	ZIC3 →	+0.522	+4.867	<.001	.009	3	2
BLOOD_Myeloma	ATXN3L →	+0.443	+3.906	.008	.009	3	1
BLOOD_Myeloma	DMRTB1 →	+0.014	+4.285	<.001	.003	3	1
BLOOD_Myeloma	TPPP2 →	+0.052	+4.285	<.001	.003	3	1
BLOOD_Myeloma	TRARG1 →	+0.006	+3.906	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 159 associations by consensus.

Exploration

COL28A1 survival (RNA) · tumor vs normal (RNA) · all COL28A1 data types