Across TCGA pan-cancer cohorts, COL27A1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated COL27A1 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher COL27A1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated COL27A1 expression acts as an unfavorable survival marker, although some lineages such as STAD and SKCM show a favorable association.

STAD, LGG, and SKCM are the cancer types where COL27A1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Median	II,III,IV	0.891	0.363	.016	17	view →
LGG	OS	Median	All	0.294	0.799	.005	3	view →
SKCM	DFS	Median	All	0.525	0.207	.026	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: COL27A1 tumor-vs-normal RNA expression · all COL27A1 data types