Across TCGA patient cohorts, COL27A1 mutation is significantly associated with the RNA expression of many other genes, with 4,685 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL27A1-associated genes across cancer lineages are WNT4, RAD51, and ZWINT. Each is linked with COL27A1 in more than 4 cancer types. Because this analysis shows association rather than direction, both COL27A1-to-partner and partner-to-COL27A1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL27A1→partner) and Y-score (partner→COL27A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	WNT4 →	-1.014	-3.568	.001	.002	3	5
UCEC	RAD51 →	+0.700	+1.513	<.001	<.001	3	5
UCEC	ZWINT →	+0.568	+2.283	<.001	<.001	3	4
STAD	KLF16 →	+0.575	+3.194	.006	.009	2	5
SKCM	HERC6 →	-0.601	-1.612	.005	.003	3	4
SKCM	MKI67 →	+0.578	+2.334	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,685 associations by consensus.

Exploration

COL27A1 survival (RNA) · tumor vs normal (RNA) · all COL27A1 data types