Across TCGA patient cohorts, COL27A1 mutation is significantly associated with the total protein of many other genes, with 74 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL27A1-associated genes across cancer lineages are ASNS, eEF2, and Rab25. Each is linked with COL27A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both COL27A1-to-partner and partner-to-COL27A1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL27A1→partner) and Y-score (partner→COL27A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ASNS →	+0.479	+3.321	.021	.010	3	3
UCEC	eEF2 →	+0.210	+1.157	.034	.014	3	3
UCEC	Rab25 →	-0.306	-1.289	<.001	.021	3	3
UCEC	ATM →	-0.491	-1.678	<.001	<.001	3	3
COAD	Caspase-7-cleavedD198 →	+0.924	+1.765	<.001	.012	3	3
UCEC	4E-BP1 →	+0.213	+1.807	.004	.024	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

Exploration

COL27A1 survival (RNA) · tumor vs normal (RNA) · all COL27A1 data types