COL27A1

mutation — cross-omics
Cross-omicsMUTATION → RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, COL27A1 mutation is significantly associated with the RNA expression of many other genes, with 2,074 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COL27A1-associated genes across cancer lineages are S100G, APBB2, and TRARG1. Each is linked with COL27A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COL27A1-to-partner and partner-to-COL27A1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL27A1→partner) and Y-score (partner→COL27A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
STOMACHS100G →+0.174+3.247.004.00332
UPPER_AERODIGESTIVE_TRACTAPBB2 →+1.070+3.067.002.00932
LUNG_NSCLC_LUADTRARG1 →+0.010+4.343<.001.00232
BLOOD_LeukemiaMTRNR2L6 →+0.052+3.269<.001.00732
LARGE_INTESTINECCDC134 →+0.819+2.364<.001<.00132
LARGE_INTESTINECCNI →+0.607+2.451<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 2,074 associations by consensus.

Exploration