Across TCGA patient cohorts, COL25A1 mutation is significantly associated with the RNA expression of many other genes, with 4,652 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL25A1-associated genes across cancer lineages are PBK, SKA1, and KIF15. Each is linked with COL25A1 in more than 4 cancer types. Because this analysis shows association rather than direction, both COL25A1-to-partner and partner-to-COL25A1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL25A1→partner) and Y-score (partner→COL25A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PBK →	+0.852	+2.379	<.001	<.001	3	5
UCEC	SKA1 →	+0.645	+2.110	<.001	<.001	3	4
UCEC	KIF15 →	+0.587	+2.338	.001	<.001	3	4
UCEC	ABRAXAS2 →	+0.361	+2.110	.001	<.001	3	4
UCEC	GTSE1 →	+0.666	+2.163	<.001	<.001	3	4
UCEC	SPAG5 →	+0.616	+2.369	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,652 associations by consensus.

Exploration

COL25A1 survival (RNA) · tumor vs normal (RNA) · all COL25A1 data types