Across TCGA cell cohorts, COL25A1 mutation is significantly associated with the RNA expression of many other genes, with 81 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible COL25A1-associated genes across cancer lineages are FAHD2A, DPRX, and CBLIF. Each is linked with COL25A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COL25A1-to-partner and partner-to-COL25A1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL25A1→partner) and Y-score (partner→COL25A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAHD2A →	+0.497	+3.082	.002	.007	3	2
OVARY	DPRX →	+0.080	+3.339	<.001	.004	3	2
SOFT_TISSUE	CBLIF →	+0.096	+4.635	<.001	.003	3	1
LUNG_NSCLC_LUSC	RBMY1E →	+0.820	+4.643	.002	.008	3	1
PANCREAS	ZNF835 →	+0.035	+4.011	<.001	.009	3	1
PANCREAS	UBE2U →	+0.285	+4.011	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

Exploration

COL25A1 survival (RNA) · tumor vs normal (RNA) · all COL25A1 data types