COL23A1

Across TCGA patient cohorts, COL23A1 mutation is significantly associated with the RNA expression of many other genes, with 1,751 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL23A1-associated genes across cancer lineages are CCDC134, NCAPH2, and SFXN1. Each is linked with COL23A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both COL23A1-to-partner and partner-to-COL23A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC134 grouped by COL23A1-low versus COL23A1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL23A1→partner) and Y-score (partner→COL23A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CCDC134 →	+0.549	+2.421	.001	.002	3	3
SKCM	NCAPH2 →	+0.570	+2.622	<.001	.005	3	3
UCEC	SFXN1 →	+0.403	+3.073	.002	<.001	3	3
COAD	RNU6-1169P →	+0.233	+3.062	.006	.001	3	3
UCEC	FANCG →	+0.435	+2.595	.004	.005	3	3
UCEC	NDUFA6 →	+0.416	+3.828	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,751 associations by consensus.

CCDC134 by COL23A1 expression — SKCM

Explore this box plot interactively →