COL23A1

Across TCGA patient cohorts, COL23A1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL23A1-associated genes across cancer lineages are Chk1, ATM, and HSP70. Each is linked with COL23A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both COL23A1-to-partner and partner-to-COL23A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk1 grouped by COL23A1-low versus COL23A1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL23A1→partner) and Y-score (partner→COL23A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Chk1 →	+0.314	+2.815	.010	.036	2	3
UCEC	ATM →	-0.701	-3.247	<.001	<.001	3	2
SKCM	HSP70 →	-0.622	-3.157	.010	.018	3	1
SKCM	p38-MAPK_pT180_Y182 →	-0.346	-3.000	.032	.035	2	2
SKCM	Chk2 →	+0.282	+3.169	.006	.018	3	1
SKCM	Collagen-VI →	-0.361	-3.000	.023	.035	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Chk1 by COL23A1 expression — COAD

Explore this box plot interactively →