COL22A1

Across TCGA pan-cancer cohorts, COL22A1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated COL22A1 data layer compared with 24 for mass-spec protein and 13 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher COL22A1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COL22A1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

COAD, HNSC, and CCRCC are the cancer types where COL22A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.838	1.000	.045	12	view →
HNSC	DFS	Tertile	All	0.918	0.747	.025	10	view →
CCRCC	DFS	Median	All	0.868	0.360	.018	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

COL22A1–COAD (DFS)

Open the COAD breakdown →