COL22A1

Across TCGA patient cohorts, COL22A1 mutation is significantly associated with the total protein of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL22A1-associated genes across cancer lineages are Cyclin-B1, GAPDH, and JNK_pT183_Y185. Each is linked with COL22A1 in more than 6 cancer types. Because this analysis shows association rather than direction, both COL22A1-to-partner and partner-to-COL22A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by COL22A1-low versus COL22A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL22A1→partner) and Y-score (partner→COL22A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.564	+1.691	<.001	<.001	3	7
COAD	GAPDH →	+0.397	+3.321	.012	.009	3	5
UCEC	JNK_pT183_Y185 →	-0.117	-1.263	.004	.014	3	4
BRCA	ER-alpha →	-1.814	-2.321	.003	.037	3	4
HNSC	PEA-15 →	-0.223	-3.000	.043	.033	3	4
UCEC	eIF4E →	+0.213	+1.841	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

Cyclin-B1 by COL22A1 expression — UCEC

Explore this box plot interactively →