COL22A1

Across TCGA cell cohorts, COL22A1 mutation is significantly associated with the RNA expression of many other genes, with 1,342 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible COL22A1-associated genes across cancer lineages are ACYP1, SDC4, and RABL2B. Each is linked with COL22A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both COL22A1-to-partner and partner-to-COL22A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACYP1 grouped by COL22A1-low versus COL22A1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL22A1→partner) and Y-score (partner→COL22A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ACYP1 →	+0.984	+3.199	<.001	.007	3	3
LARGE_INTESTINE	SDC4 →	-0.892	-1.906	.006	.001	3	3
BREAST	RABL2B →	+0.863	+3.220	.002	.005	3	3
SKIN	CFP →	-0.236	-3.102	.002	.009	3	2
SKIN	BDH2 →	+0.658	+2.743	.005	.001	2	3
CNS	OR4A47 →	+0.018	+4.357	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,342 associations by consensus.

ACYP1 by COL22A1 expression — BLOOD_Leukemia

Explore this box plot interactively →