COL22A1

Across TCGA cell cohorts, COL22A1 mutation is significantly associated with the mutation status of many other genes, with 4,343 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible COL22A1-associated genes across cancer lineages are LAMA2, RTL1, and MYH8. Each is linked with COL22A1 in more than 6 cancer types. Because this analysis shows association rather than direction, both COL22A1-to-partner and partner-to-COL22A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LAMA2 grouped by COL22A1-low versus COL22A1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL22A1→partner) and Y-score (partner→COL22A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	LAMA2 →	+2.181	+1.876	.003	.003	1	7
UPPER_AERODIGESTIVE_TRACT	RTL1 →	+4.247	+2.954	.006	.006	1	7
BONE	MYH8 →	+4.240	+4.240	.001	.001	1	6
BONE	MYO18B →	+3.240	+3.708	.006	.006	1	6
OVARY	MYH7 →	+3.345	+3.345	.007	.007	1	6
BLOOD_Leukemia	MYH4 →	+2.230	+1.965	.005	.005	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,343 associations by consensus.

LAMA2 by COL22A1 expression — SKIN

Explore this box plot interactively →