COL21A1

Across TCGA pan-cancer cohorts, COL21A1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated COL21A1 data layer compared with 22 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher COL21A1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated COL21A1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where COL21A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.957	0.665	.002	46	view →
LUAD	DFS	Median	II,III,IV	0.660	0.994	<.001	14	view →
PDAC	OS	Median	All	1.000	0.888	.010	7	view →
GBM	DFS	Median	All	0.247	0.518	.023	6	view →
UCEC	OS	Median	III,IV	0.355	1.000	.013	4	view →
LSCC	OS	Median	II,III,IV	0.884	0.701	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

COL21A1–CCRCC (OS)

Open the CCRCC breakdown →