COL21A1

Across TCGA patient cohorts, COL21A1 protein abundance is significantly associated with the RNA expression of many other genes, with 9,154 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible COL21A1-associated genes across cancer lineages are ERG, PLPP1, and FHL5. Each is linked with COL21A1 in more than 4 cancer types. Because this analysis shows association rather than direction, both COL21A1-to-partner and partner-to-COL21A1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COL21A1 versus ERG in UCEC, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL21A1→partner) and Y-score (partner→COL21A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERG →	+0.793	+0.700	.001	.005	2	5
CCRCC	PLPP1 →	+1.277	+1.295	<.001	<.001	3	4
CCRCC	FHL5 →	+1.032	+0.911	<.001	.001	3	4
CCRCC	SOCS2 →	+1.044	+1.091	<.001	<.001	3	4
OV	CD36 →	+1.594	+0.714	.004	.007	3	4
OV	ABCA8 →	+1.256	+0.765	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,154 associations by consensus.

COL21A1 vs ERG — UCEC

Explore this scatter interactively →