COL21A1

Across TCGA patient cohorts, COL21A1 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL21A1-associated genes across cancer lineages are INPP4B, Rab25, and 4E-BP1. Each is linked with COL21A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both COL21A1-to-partner and partner-to-COL21A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by COL21A1-low versus COL21A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL21A1→partner) and Y-score (partner→COL21A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.219	-1.584	.029	.015	3	3
UCEC	Rab25 →	-0.325	-2.662	.001	<.001	3	3
UCEC	4E-BP1 →	+0.296	+3.169	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.628	+2.502	<.001	.001	3	3
UCEC	GATA6 →	-0.122	-1.792	.011	.023	3	2
UCEC	PEA-15_pS116 →	+0.323	+1.415	.003	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

INPP4B by COL21A1 expression — UCEC

Explore this box plot interactively →