COL21A1

Across TCGA cell cohorts, COL21A1 mutation is significantly associated with the RNA expression of many other genes, with 224 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COL21A1-associated genes across cancer lineages are MRPS7, SLC25A19, and CCDC43. Each is linked with COL21A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COL21A1-to-partner and partner-to-COL21A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS7 grouped by COL21A1-low versus COL21A1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL21A1→partner) and Y-score (partner→COL21A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MRPS7 →	+0.563	+3.295	<.001	.003	3	2
SKIN	SLC25A19 →	+0.765	+3.321	.001	.003	3	2
SKIN	CCDC43 →	+0.480	+2.451	<.001	.009	3	2
LARGE_INTESTINE	MLX →	+0.412	+3.628	.003	<.001	3	2
LARGE_INTESTINE	CHAC2 →	+0.703	+2.502	.003	.005	3	2
LUNG_NSCLC_LUSC	ATP6V1G3 →	+0.254	+4.108	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 224 associations by consensus.

MRPS7 by COL21A1 expression — SKIN

Explore this box plot interactively →