COL20A1

Across TCGA cell cohorts, COL20A1 mutation is significantly associated with the RNA expression of many other genes, with 719 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COL20A1-associated genes across cancer lineages are ADAM2, SOD2, and SEMG2. Each is linked with COL20A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COL20A1-to-partner and partner-to-COL20A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM2 grouped by COL20A1-low versus COL20A1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL20A1→partner) and Y-score (partner→COL20A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ADAM2 →	+0.132	+4.217	<.001	.005	3	2
LARGE_INTESTINE	SOD2 →	+0.833	+3.321	<.001	.003	3	2
LARGE_INTESTINE	SEMG2 →	+0.362	+2.041	.001	.007	3	2
LARGE_INTESTINE	NFIB →	+1.210	+2.451	.001	.009	3	2
LARGE_INTESTINE	PGAP4 →	+1.133	+3.502	.003	.001	3	2
LARGE_INTESTINE	ADH1A →	+0.106	+2.920	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 719 associations by consensus.

ADAM2 by COL20A1 expression — URINARY_TRACT

Explore this box plot interactively →