COL1A2

Across TCGA pan-cancer cohorts, COL1A2 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated COL1A2 data layer compared with 25 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher COL1A2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated COL1A2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

OV, BRCA, and PAAD are the cancer types where COL1A2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Median	All	0.231	0.542	.016	18	view →
BRCA	OS	Median	III,IV	0.500	0.906	.003	10	view →
PAAD	DFS	Median	All	0.112	0.504	.025	6	view →
PRAD	DFS	Median	All	0.617	0.886	.045	6	view →
UCEC	DFS	Median	All	0.900	0.616	.024	6	view →
LIHC	OS	Median	All	0.098	0.774	.001	6	view →
KIRP	OS	Median	All	0.192	0.705	.015	4	view →
READ	OS	Median	II,III,IV	0.567	0.821	.021	3	view →
COAD	DFS	Median	IV	0.193	0.502	.008	3	view →
BLCA	OS	Median	III,IV	0.101	0.410	.023	2	view →
SKCM	DFS	Median	IV	1.000	0.201	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

COL1A2–OV (DFS)

Open the OV breakdown →