COL1A2

Across TCGA pan-cancer cohorts, COL1A2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COL1A2 data layer compared with 25 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher COL1A2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COL1A2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

PDAC, LSCC, and HNSC are the cancer types where COL1A2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.251	0.508	.003	32	view →
LSCC	DFS	Tertile	All	0.580	0.876	.001	25	view →
HNSC	DFS	Median	II,III,IV	0.967	0.904	.034	6	view →
CCRCC	OS	Median	All	0.948	0.845	.028	2	view →
LUAD	OS	Tertile	All	0.818	0.936	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

COL1A2–PDAC (DFS)

Open the PDAC breakdown →