COL1A1

Across TCGA pan-cancer cohorts, COL1A1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated COL1A1 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher COL1A1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COL1A1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LSCC, PDAC, and COAD are the cancer types where COL1A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.562	0.843	.003	24	view →
PDAC	OS	Quartile	All	0.244	0.482	.007	23	view →
COAD	DFS	Median	III,IV	0.893	1.000	.037	12	view →
GBM	DFS	Tertile	All	0.659	0.803	.011	10	view →
LUAD	OS	Median	All	0.769	0.905	.010	6	view →
HNSC	DFS	Median	II,III,IV	0.967	0.904	.034	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

COL1A1–LSCC (DFS)

Open the LSCC breakdown →