COL1A1

Across TCGA patient cohorts, COL1A1 protein abundance is significantly associated with the RNA expression of many other genes, with 16,734 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible COL1A1-associated genes across cancer lineages are LAMA4, PDGFRB, and ISLR. Each is linked with COL1A1 in more than 9 cancer types. Because this analysis shows association rather than direction, both COL1A1-to-partner and partner-to-COL1A1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COL1A1 versus LAMA4 in BRCA, with a Pearson correlation of 0.71.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL1A1→partner) and Y-score (partner→COL1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LAMA4 →	+1.152	+1.020	<.001	<.001	3	10
OV	PDGFRB →	+1.812	+0.899	<.001	<.001	3	10
GBM	ISLR →	+1.486	+1.199	<.001	<.001	3	10
OV	COL5A1 →	+2.123	+0.930	<.001	<.001	3	10
BRCA	ITGA11 →	+1.615	+0.773	<.001	<.001	3	10
COAD	EMILIN1 →	+1.271	+0.988	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,734 associations by consensus.

COL1A1 vs LAMA4 — BRCA

Explore this scatter interactively →