COL1A1

Across TCGA patient cohorts, COL1A1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL1A1-associated genes across cancer lineages are JNK2, MSH6, and eEF2. Each is linked with COL1A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both COL1A1-to-partner and partner-to-COL1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by COL1A1-low versus COL1A1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL1A1→partner) and Y-score (partner→COL1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	JNK2 →	+0.485	+2.834	<.001	.034	3	3
UCEC	MSH6 →	-0.317	-1.584	.002	.032	3	3
UCEC	eEF2 →	+0.246	+2.459	.031	.018	3	3
UCEC	mTOR →	-0.146	-1.700	.004	.040	3	3
UCEC	Cyclin-B1 →	+0.358	+1.874	.046	.049	3	3
STAD	Claudin-7 →	+0.834	+3.000	.006	.034	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

JNK2 by COL1A1 expression — LUSC

Explore this box plot interactively →