COL1A1

Across TCGA cell cohorts, COL1A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,566 significant associations in total. BONE shows the largest number of these associations.

The most reproducible COL1A1-associated GO terms across cancer lineages are Collagen biosynthetic process, Endosomal transport, and Vesicle-mediated transport to the plasma membrane. Each is linked with COL1A1 in more than 14 cancer types. Because this analysis shows association rather than direction, both COL1A1-to-partner and partner-to-COL1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Collagen biosynthetic process grouped by COL1A1-low versus COL1A1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COL1A1→partner) and Y-score (partner→COL1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Collagen biosynthetic process →	+0.292	+5.554	<.001	<.001	3	15
OESOPHAGUS	Endosomal transport →	+0.072	+2.550	.001	.005	3	15
BONE	Vesicle-mediated transport to the plasma membrane →	+0.075	+6.293	<.001	<.001	3	15
BONE	Wound healing →	+0.134	+5.959	<.001	<.001	3	14
BONE	Regulation of actomyosin structure organization →	+0.105	+5.414	<.001	<.001	3	14
LIVER	Maintenance of protein localization in organelle →	+0.161	+4.841	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,566 associations by consensus.

Collagen biosynthetic process by COL1A1 expression — LIVER

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