COL1A1

Across TCGA cell cohorts, COL1A1 mutation is significantly associated with the RNA expression of many other genes, with 236 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COL1A1-associated genes across cancer lineages are OR13D1, TBX18, and WRAP73. Each is linked with COL1A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COL1A1-to-partner and partner-to-COL1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13D1 grouped by COL1A1-low versus COL1A1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL1A1→partner) and Y-score (partner→COL1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR13D1 →	+0.050	+2.956	<.001	.008	3	2
LARGE_INTESTINE	TBX18 →	+1.041	+3.228	<.001	.009	3	2
LARGE_INTESTINE	WRAP73 →	+0.564	+3.364	.002	.002	3	2
LARGE_INTESTINE	GALR3 →	+0.097	+2.646	<.001	.006	3	2
BLOOD_Leukemia	BHLHE23 →	+0.848	+3.954	.008	.001	3	2
URINARY_TRACT	HTR1A →	+0.030	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 236 associations by consensus.

OR13D1 by COL1A1 expression — BLOOD_Lymphoma

Explore this box plot interactively →