Across TCGA pan-cancer cohorts, COL18A1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated COL18A1 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher COL18A1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated COL18A1 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

PDAC, LSCC, and CCRCC are the cancer types where COL18A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.862	0.644	.004	10	view →
LSCC	DFS	Median	II,III,IV	0.830	1.000	.003	7	view →
CCRCC	DFS	Tertile	IV	0.238	0.887	.024	6	view →
LUAD	OS	Tertile	All	0.927	1.000	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: COL18A1 tumor-vs-normal RNA expression · all COL18A1 data types