Across TCGA patient cohorts, COL18A1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,008 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible COL18A1-associated genes across cancer lineages are C7, SGCA, and CYGB. Each is linked with COL18A1 in more than 9 cancer types. Because this analysis shows association rather than direction, both COL18A1-to-partner and partner-to-COL18A1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL18A1→partner) and Y-score (partner→COL18A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	C7 →	+2.324	+0.307	<.001	<.001	3	10
HNSC	SGCA →	+1.114	+0.285	<.001	.004	3	9
OV	CYGB →	+1.095	+0.417	<.001	<.001	3	9
BRCA	RHOJ →	+0.957	+0.487	<.001	<.001	3	8
COAD	CDO1 →	+0.895	+0.507	<.001	<.001	2	9
CCRCC	FBLN5 →	+1.266	+0.294	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,008 associations by consensus.

Exploration

COL18A1 survival (RNA) · tumor vs normal (RNA) · all COL18A1 data types