Across TCGA patient cohorts, COL18A1 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL18A1-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and Cyclin-E2. Each is linked with COL18A1 in more than 3 cancer types. Because this analysis shows association rather than direction, both COL18A1-to-partner and partner-to-COL18A1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL18A1→partner) and Y-score (partner→COL18A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.215	+1.815	.004	.002	3	4
COAD	Caspase-7-cleavedD198 →	+0.952	+2.087	<.001	.004	3	4
STAD	Cyclin-E2 →	+0.241	+2.828	.001	.035	3	3
COAD	Smad4 →	+0.088	+1.807	.031	.022	3	3
UCEC	ATM →	-0.439	-3.074	.001	<.001	3	3
COAD	Chk1 →	+0.217	+3.321	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

Exploration

COL18A1 survival (RNA) · tumor vs normal (RNA) · all COL18A1 data types