Across TCGA patient cohorts, COL15A1 mutation is significantly associated with the total protein of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL15A1-associated genes across cancer lineages are Cyclin-B1, Acetyl-a-Tubulin-Lys40, and Myosin-IIa_pS1943. Each is linked with COL15A1 in more than 3 cancer types. Because this analysis shows association rather than direction, both COL15A1-to-partner and partner-to-COL15A1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL15A1→partner) and Y-score (partner→COL15A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.704	+2.169	<.001	<.001	3	4
STAD	Acetyl-a-Tubulin-Lys40 →	-0.384	-3.000	.025	.036	3	3
STAD	Myosin-IIa_pS1943 →	+0.631	+3.000	.022	.036	3	3
LUSC	14-3-3_beta →	-0.105	-3.151	.018	.017	3	3
UCEC	Notch1 →	+0.164	+1.415	<.001	.002	3	3
COAD	eEF2 →	+0.371	+2.593	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

Exploration

COL15A1 survival (RNA) · tumor vs normal (RNA) · all COL15A1 data types