Across TCGA pan-cancer cohorts, COL14A1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated COL14A1 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher COL14A1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated COL14A1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC, CCRCC, and GBM are the cancer types where COL14A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.817	0.604	.004	30	view →
CCRCC	DFS	Median	III,IV	0.399	0.932	.022	18	view →
GBM	OS	Quartile	All	0.246	0.610	.007	8	view →
LUAD	DFS	Tertile	All	0.789	0.491	.003	7	view →
COAD	DFS	Median	III,IV	1.000	0.831	.027	6	view →
LSCC	DFS	Tertile	II,III,IV	0.772	0.945	.022	5	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: COL14A1 tumor-vs-normal RNA expression · all COL14A1 data types