COL12A1

Across TCGA pan-cancer cohorts, COL12A1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated COL12A1 data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher COL12A1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COL12A1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, LSCC, and CCRCC are the cancer types where COL12A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.295	0.536	<.001	43	view →
LSCC	DFS	Median	All	0.584	0.828	.002	27	view →
CCRCC	DFS	Tertile	II,III,IV	0.177	0.979	.010	13	view →
COAD	DFS	Median	All	0.887	1.000	.021	12	view →
HNSC	DFS	Median	All	0.970	0.915	.042	2	view →
GBM	OS	Median	All	0.788	0.921	.021	2	view →
LUAD	OS	Median	All	0.788	0.966	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

COL12A1–PDAC (DFS)

Open the PDAC breakdown →