COL12A1

Across TCGA patient cohorts, COL12A1 mutation is significantly associated with the RNA expression of many other genes, with 7,662 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL12A1-associated genes across cancer lineages are ZWINT, CKS2, and PIMREG. Each is linked with COL12A1 in more than 5 cancer types. Because this analysis shows association rather than direction, both COL12A1-to-partner and partner-to-COL12A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZWINT grouped by COL12A1-low versus COL12A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL12A1→partner) and Y-score (partner→COL12A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZWINT →	+0.751	+1.807	<.001	<.001	3	6
UCEC	CKS2 →	+0.660	+1.554	<.001	<.001	3	6
UCEC	PIMREG →	+0.658	+1.457	<.001	<.001	3	6
UCEC	HMGB2 →	+0.533	+1.232	<.001	<.001	3	6
UCEC	DEPDC1 →	+0.549	+1.332	<.001	<.001	3	6
UCEC	CDKN3 →	+0.720	+1.818	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,662 associations by consensus.

ZWINT by COL12A1 expression — UCEC

Explore this box plot interactively →