COL12A1

Across TCGA patient cohorts, COL12A1 mutation is significantly associated with the total protein of many other genes, with 102 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL12A1-associated genes across cancer lineages are INPP4B, Cyclin-E2, and Caspase-7-cleavedD198. Each is linked with COL12A1 in more than 4 cancer types. Because this analysis shows association rather than direction, both COL12A1-to-partner and partner-to-COL12A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by COL12A1-low versus COL12A1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL12A1→partner) and Y-score (partner→COL12A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	INPP4B →	-0.316	-2.169	.002	.002	3	5
BLCA	Cyclin-E2 →	+0.196	+2.906	.005	.001	3	5
COAD	Caspase-7-cleavedD198 →	+0.891	+2.923	<.001	<.001	3	5
UCEC	4E-BP1 →	+0.325	+1.378	<.001	<.001	3	4
BLCA	ER-alpha_pS118 →	+0.100	+2.222	.032	.010	3	4
BLCA	Smad1 →	+0.144	+2.824	.025	.034	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 102 associations by consensus.

INPP4B by COL12A1 expression — COAD

Explore this box plot interactively →