COL12A1

Across TCGA cell cohorts, COL12A1 mutation is significantly associated with the RNA expression of many other genes, with 755 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COL12A1-associated genes across cancer lineages are SLC25A17, ZNF644, and GCH1. Each is linked with COL12A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both COL12A1-to-partner and partner-to-COL12A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A17 grouped by COL12A1-low versus COL12A1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL12A1→partner) and Y-score (partner→COL12A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC25A17 →	+0.526	+2.043	.001	.001	3	3
LARGE_INTESTINE	ZNF644 →	+0.409	+3.087	<.001	.006	3	3
LARGE_INTESTINE	GCH1 →	+0.448	+1.628	.008	.007	3	3
LARGE_INTESTINE	SLC39A6 →	+0.672	+3.082	.009	.007	3	3
LARGE_INTESTINE	EIF4ENIF1 →	+0.470	+2.115	.001	.004	3	3
LARGE_INTESTINE	ADH5 →	+0.511	+3.252	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 755 associations by consensus.

SLC25A17 by COL12A1 expression — LARGE_INTESTINE

Explore this box plot interactively →