COL10A1

Across TCGA pan-cancer cohorts, COL10A1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated COL10A1 data layer compared with 19 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher COL10A1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated COL10A1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

PDAC, LUAD, and HNSC are the cancer types where COL10A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.283	0.481	.001	40	view →
LUAD	DFS	Median	II,III,IV	1.000	0.766	.035	14	view →
HNSC	DFS	Median	II,III,IV	1.000	0.907	.007	6	view →
LSCC	DFS	Median	All	0.897	0.692	.010	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

COL10A1–PDAC (OS)

Open the PDAC breakdown →