COL10A1

Across TCGA pan-cancer cohorts, COL10A1 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of COL10A1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where COL10A1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types COL10A1 is over-expressed in tumor.

HNSC, PDAC, and LUAD are the cancer types where COL10A1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COL10A1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.800	<.001	8	view →
PDAC	Female	All	+1.196	<.001	7	view →
LUAD	All	All	+0.355	.014	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

COL10A1–HNSC

Open the HNSC breakdown →