COL10A1

Across TCGA patient cohorts, COL10A1 mutation is significantly associated with the RNA expression of many other genes, with 3,211 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL10A1-associated genes across cancer lineages are JOSD1, SEC23B, and AAGAB. Each is linked with COL10A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COL10A1-to-partner and partner-to-COL10A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JOSD1 grouped by COL10A1-low versus COL10A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL10A1→partner) and Y-score (partner→COL10A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JOSD1 →	+0.394	+2.050	<.001	<.001	3	2
UCEC	SEC23B →	+0.489	+1.627	.003	.001	3	2
UCEC	AAGAB →	+0.458	+2.364	<.001	<.001	3	2
UCEC	GARS1 →	+0.393	+2.130	<.001	.002	3	2
UCEC	CREB3 →	+0.264	+2.534	.006	<.001	3	2
SKCM	GIT1 →	+0.510	+3.258	.002	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,211 associations by consensus.

JOSD1 by COL10A1 expression — UCEC

Explore this box plot interactively →