COL10A1

Across TCGA cell cohorts, COL10A1 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible COL10A1-associated genes across cancer lineages are SIGLEC5, CD93, and CCDC175. Each is linked with COL10A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COL10A1-to-partner and partner-to-COL10A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC5 grouped by COL10A1-low versus COL10A1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL10A1→partner) and Y-score (partner→COL10A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SIGLEC5 →	+0.211	+2.896	.002	.008	3	1
LUNG_NSCLC_LUAD	CD93 →	+0.067	+4.000	.001	.004	3	1
LUNG_NSCLC_LUAD	CCDC175 →	+0.074	+3.693	.001	.005	3	1
LUNG_NSCLC_LUAD	KLHL40 →	+0.014	+2.896	<.001	.008	3	1
LUNG_NSCLC_LUAD	TEX55 →	+0.045	+3.092	.002	.005	3	1
LUNG_NSCLC_LUAD	TEX33 →	+0.015	+3.944	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

SIGLEC5 by COL10A1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →