COIL

Across TCGA pan-cancer cohorts, COIL mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COIL data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher COIL mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated COIL expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

COAD, HNSC, and LSCC are the cancer types where COIL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.920	.014	24	view →
HNSC	DFS	Quartile	All	0.371	0.871	.014	14	view →
LSCC	OS	Quartile	III,IV	0.516	0.925	.038	6	view →
LUAD	DFS	Median	II,III,IV	0.955	0.751	.040	3	view →
CCRCC	DFS	Quartile	All	0.696	0.871	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

COIL–COAD (DFS)

Open the COAD breakdown →