Across TCGA patient cohorts, COG8 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COG8-associated genes across cancer lineages are PEA-15_pS116, PI3K-p110-a, and S6_pS240_S244. Each is linked with COG8 in more than 1 cancer types. Because this analysis shows association rather than direction, both COG8-to-partner and partner-to-COG8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COG8→partner) and Y-score (partner→COG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PEA-15_pS116 →	+0.527	+3.169	.006	.020	3	1
SKCM	PI3K-p110-a →	+0.165	+3.459	.031	.005	3	1
SKCM	S6_pS240_S244 →	-0.465	-2.982	.025	.034	3	1
UCEC	c-Kit →	-0.288	-3.169	.024	.020	2	1
UCEC	VHL →	-1.583	-3.169	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

COG8 survival (RNA) · tumor vs normal (RNA) · all COG8 data types