Across TCGA cell cohorts, COG8 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible COG8-associated genes across cancer lineages are ODF1, SYCN, and USP17L3. Each is linked with COG8 in more than 1 cancer types. Because this analysis shows association rather than direction, both COG8-to-partner and partner-to-COG8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COG8→partner) and Y-score (partner→COG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ODF1 →	+0.026	+6.022	<.001	.001	3	1
BLOOD_Leukemia	SYCN →	+0.047	+5.539	<.001	.003	3	1
BLOOD_Leukemia	USP17L3 →	+0.012	+4.922	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

COG8 survival (RNA) · tumor vs normal (RNA) · all COG8 data types