COG6

Across TCGA pan-cancer cohorts, COG6 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated COG6 data layer compared with 28 for mass-spec protein and 8 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher COG6 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated COG6 expression acts as an unfavorable survival marker.

CESC, READ, and COAD are the cancer types where COG6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	II,III,IV	0.144	0.705	.004	18	view →
READ	OS	Median	II,III,IV	0.054	0.934	<.001	18	view →
COAD	DFS	Median	All	0.192	0.696	.005	18	view →
PRAD	DFS	Median	All	0.171	0.888	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

COG6–CESC (DFS)

Open the CESC breakdown →