COG6

Across TCGA pan-cancer cohorts, COG6 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated COG6 data layer compared with 28 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher COG6 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated COG6 expression acts as an unfavorable survival marker, although some lineages such as UCEC and COAD show a favorable association.

UCEC, COAD, and LUAD are the cancer types where COG6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.991	0.816	<.001	36	view →
COAD	DFS	Median	II,III,IV	1.000	0.912	.013	24	view →
LUAD	OS	Tertile	III,IV	0.842	0.299	.005	24	view →
HNSC	OS	Median	III,IV	0.449	1.000	.023	21	view →
LSCC	DFS	Quartile	All	0.908	1.000	.007	11	view →
PDAC	DFS	Tertile	IV	0.217	0.749	.024	9	view →
GBM	OS	Quartile	All	0.315	0.564	.020	2	view →
CCRCC	DFS	Tertile	III,IV	0.598	0.837	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

COG6–UCEC (DFS)

Open the UCEC breakdown →