COG6

Across TCGA patient cohorts, COG6 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,400 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible COG6-associated proteins across cancer lineages are GPALPP1, ZMYM2, and SUGT1. Each is linked with COG6 in more than 6 cancer types. Because this analysis shows association rather than direction, both COG6-to-partner and partner-to-COG6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COG6 versus GPALPP1 in LSCC, with a Pearson correlation of 0.46.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (COG6→partner) and Y-score (partner→COG6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GPALPP1 →	+0.388	+0.494	<.001	<.001	3	7
LSCC	ZMYM2 →	+0.512	+0.475	<.001	<.001	3	6
COAD	SUGT1 →	+0.400	+0.351	<.001	.002	3	6
GBM	ARHGEF7 →	+0.240	+0.278	<.001	<.001	3	6
UCEC	COG2 →	+0.287	+0.366	<.001	<.001	3	6
UCEC	COG3 →	+0.352	+0.490	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,400 associations by consensus.

COG6 vs GPALPP1 — LSCC

Explore this scatter interactively →