COG6

Across TCGA patient cohorts, COG6 mutation is significantly associated with the RNA expression of many other genes, with 2,896 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COG6-associated genes across cancer lineages are MIR3661, INCENP, and CPSF7. Each is linked with COG6 in more than 1 cancer types. Because this analysis shows association rather than direction, both COG6-to-partner and partner-to-COG6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3661 grouped by COG6-low versus COG6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COG6→partner) and Y-score (partner→COG6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR3661 →	+1.342	+3.829	<.001	.005	3	2
UCEC	INCENP →	+0.758	+4.031	<.001	<.001	3	2
UCEC	CPSF7 →	+0.450	+2.102	<.001	.001	3	2
UCEC	BRPF1 →	+0.483	+3.063	<.001	<.001	3	2
UCEC	INPPL1 →	+0.518	+2.459	<.001	<.001	3	2
UCEC	ENTR1 →	+0.443	+2.828	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,896 associations by consensus.

MIR3661 by COG6 expression — COAD

Explore this box plot interactively →